I have always been inspired by the complexity of the molecular mechanism of how our human genome is regulated, and whether it is possible to learn from nature to design tools that turn genes on or off.
The epigenome is a molecular code superimposed upon the genome that controls how the genetic information is read without altering the underlying DNA sequence, allowing distinct sets of genes to be turned on or off in different cell types to achieve cellular specialisation.
DNA methylation is an essential epigenetic mechanism underlying gene regulation. However, it has not been possible to specifically manipulate DNA methylation at desired locations in the genome in order to control gene expression.
My research aims to develop innovative molecular tools based on recent advanced genome editing technology to manipulate DNA methylation and other epigenetic modifications at specific locations in the genome. These tools will advance our understanding of the epigenome, and may be used for basic research and clinical application to correct aberrant epigenetic patterns in disease states such as cancer.
Research is a very time-consuming process and needs a lot of patience and dedication. The Forrest Scholarship has given me the invaluable mental and generous financial support, so I do not have to worry too much about the tuition fees and living expenses. As a result I can focus 100 per cent of my time on my research.
In addition, the Scholarship has given me a unique opportunity to train in one of the world’s laboratories at UWA in the field of epigenetics with opportunities to collaborate with leading experts.
- Company:Forrest Scholar
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7th September 2016, 08:45-10:00
Forrest Scholars Showcase Breakfast
Forrest Scholars Showcase Breakfast